In This Issue
The physician’s voice in the health care debate
Call for a slower approach to health care reform
Healing health care
The debate over health care reform
Health care reform
Academic medicine and real health care reform
An academic, apolitical approach to health care reform
Health care reform
Creating meaningful health care reform
A case for a science-informed perspective on health care reform
Health care reform — need for less emotion and more science
Reflections on health care
Research and education in health care reform
Build it and hope that enough of them will come
A view from a European medical academic who spends time in the US
Right to reform
Smallpox — the death of a disease
The end of overeating
Animal models of sepsis and sepsis-induced kidney injury
NF-κB2 (p100) limits TNF-α–induced osteoclastogenesis
Pathogenic antibodies are active participants in spinal cord injury
Reduced thymus activity and infection prematurely age the immune system
Pin1 regulates parathyroid hormone mRNA stability
Resolving lung injury
Breast cancer gene variants
CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury
SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production
Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways
Lack of Protein S in mice causes embryonic lethal coagulopathy and vascular dysgenesis
TNF-α drives remodeling of blood vessels and lymphatics in sustained airway inflammation in mice
The inability to disrupt the immunological synapse between infected human T cells and APCs distinguishes HIV-1 from most other primate lentiviruses
Restimulation-induced apoptosis of T cells is impaired in patients with X-linked lymphoproliferative disease caused by SAP deficiency
B cells produce pathogenic antibodies and impair recovery after spinal cord injury in mice
Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer
The tumor-promoting actions of TNF-α involve TNFR1 and IL-17 in ovarian cancer in mice and humans
NF-κB p100 limits TNF-induced bone resorption in mice by a TRAF3-dependent mechanism
Potent inhibition of HIV-1 by TRIM5-cyclophilin fusion proteins engineered from human components
The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice
Endogenous glucocorticoids and impaired insulin signaling are both required to stimulate muscle wasting under pathophysiological conditions in mice
Evidence of premature immune aging in patients thymectomized during early childhood
Cdc42 is an antihypertrophic molecular switch in the mouse heart
Cyclin I activates Cdk5 and regulates expression of Bcl-2 and Bcl-XL in postmitotic mouse cells
The peptidyl-prolyl isomerase Pin1 determines parathyroid hormone mRNA levels and stability in rat models of secondary hyperparathyroidism
A selective EP4 PGE2 receptor agonist alleviates disease in a new mouse model of X-linked nephrogenic diabetes insipidus
A positive FGFR3/FOXN1 feedback loop underlies benign skin keratosis versus squamous cell carcinoma formation in humans
Sumoylated PPARα mediates sex-specific gene repression and protects the liver from estrogen-induced toxicity in mice
The antiapoptotic protein Bcl-xL negatively regulates the bone-resorbing activity of osteoclasts in mice
Expression of human BRCA1 variants in mouse ES cells allows functional analysis of BRCA1 mutations
A simple biological imaging system for detecting viable human circulating tumor cells
HIF2α cooperates with RAS to promote lung tumorigenesis in mice