In This Issue
Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade
Repairing skeletal muscle
Ablation of C/EBPβ alleviates ER stress and pancreatic β cell failure through the GRP78 chaperone in mice
The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5
Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction
BTLA mediates inhibition of human tumor-specific CD8+ T cells that can be partially reversed by vaccination
CD27 sustains survival of CTLs in virus-infected nonlymphoid tissue in mice by inducing autocrine IL-2 production
Lnk regulates integrin αIIbβ3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo
Deletion of Fas in adipocytes relieves adipose tissue inflammation and hepatic manifestations of obesity in mice
Let’s keep this brief
Pregenerative medicine
Urea-induced ROS generation causes insulin resistance in mice with chronic renal failure
CD20 deficiency in humans results in impaired T cell–independent antibody responses
Genetic and epigenetic silencing of SCARA5 may contribute to human hepatocellular carcinoma by activating FAK signaling
Cardiac mast cells cause atrial fibrillation through PDGF-A–mediated fibrosis in pressure-overloaded mouse hearts
Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload
Limited forward trafficking of connexin 43 reduces cell-cell coupling in stressed human and mouse myocardium
Cardiac signaling genes exhibit unexpected sequence diversity in sporadic cardiomyopathy, revealing HSPB7 polymorphisms associated with disease
Stem cells in human neurodegenerative disorders — time for clinical translation?
TGF-β1–induced expression of human Mdm2 correlates with late-stage metastatic breast cancer
Australian scientists say “G’day USA”
Stat3-dependent acute Rantes production in vascular smooth muscle cells modulates inflammation following arterial injury in mice
The Rho/Rac exchange factor Vav2 controls nitric oxide–dependent responses in mouse vascular smooth muscle cells
IL-17 produced by neutrophils regulates IFN-γ–mediated neutrophil migration in mouse kidney ischemia-reperfusion injury
The cytolytic molecules Fas ligand and TRAIL are required for murine thymic graft-versus-host disease
FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice
Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents
Amelioration of emphysema in mice through lentiviral transduction of long-lived pulmonary alveolar macrophages
Can we keep the “academic” in academic medicine?
Palmitic acid mediates hypothalamic insulin resistance by altering PKC-q subcellular localization in rodents
A novel microRNA targeting HDAC5 regulates osteoblast differentiation in mice and contributes to primary osteoporosis in humans
Every patient tells a story
The therapeutic promise of the cancer stem cell concept
Triumph of the heart
Progress toward the clinical application of patient-specific pluripotent stem cells
Enabling stem cell therapies through synthetic stem cell–niche engineering
The bioethics of stem cell research and therapy
Putting the brakes on BTLA in T cell–mediated cancer immunotherapy
Stem cells
Sodium channels gone wild
New roles for Notch in tuberous sclerosis
Oxidant stress derails the cardiac connexon connection
Ramping up RANTES in the acute response to arterial injury
The evolutionarily conserved TSC/Rheb pathway activates Notch in tuberous sclerosis complex and Drosophila external sensory organ development