In This Issue
Siamon Gordon on the challenges of retirement
Am I making myself clear?
The role of genetic diversity in cancer
TGF-β in the pathogenesis and prevention of disease
Heart failure causes cholinergic transdifferentiation of cardiac sympathetic nerves via gp130-signaling cytokines in rodents
TGF-β activity protects against inflammatory aortic aneurysm progression and complications in angiotensin II–infused mice
Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease
Neural Wiskott-Aldrich syndrome protein modulates Wnt signaling and is required for hair follicle cycling in mice
Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells
Cardiomyocyte PDGFR-β signaling is an essential component of the mouse cardiac response to load-induced stress
CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts
Centrosomal Nlp is an oncogenic protein that is gene-amplified in human tumors and causes spontaneous tumorigenesis in transgenic mice
β-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice
The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation and tumor suppressor gene hypermethylation in mice and lung cancer patients
The T-box transcription factor Brachyury promotes epithelial-mesenchymal transition in human tumor cells
Deleted in breast cancer–1 regulates SIRT1 activity and contributes to high-fat diet–induced liver steatosis in mice
Conventional DCs reduce liver ischemia/reperfusion injury in mice via IL-10 secretion
TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis in mice
Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in mice
c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis
Using 3 TLR ligands as a combination adjuvant induces qualitative changes in T cell responses needed for antiviral protection in mice
Constitutively active phosphatase inhibitor-1 improves cardiac contractility in young mice but is deleterious after catecholaminergic stress and with aging
Statins protect against fulminant pneumococcal infection and cytolysin toxicity in a mouse model of sickle cell disease
Cellular and genetic diversity in the progression of in situ human breast carcinomas to an invasive phenotype
A positive FGFR3/FOXN1 feedback loop underlies benign skin keratosis versus squamous cell carcinoma formation in humans
Latent TGF-β–binding protein 4 modifies muscular dystrophy in mice