In This Issue
A tribute to Helen M. Ranney
Betsy Nabel
The immortal life of Henrietta Lacks
Genius on the edge
Chronic myeloid leukemia
Location, location, location
An energetic tale of AMPK-independent effects of metformin
Radioprotection
A balancing act for autophagin
Rapid progress for non-nuclear estrogen receptor signaling
GSK-3α directly regulates β-adrenergic signaling and the response of the heart to hemodynamic stress in mice
Periostin advances atherosclerotic and rheumatic cardiac valve degeneration by inducing angiogenesis and MMP production in humans and rodents
Junb regulates arterial contraction capacity, cellular contractility, and motility via its target Myl9 in mice
Non-nuclear estrogen receptor α signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice
Autophagy is essential for mouse sense of balance
Efficient and stable MGMT-mediated selection of long-term repopulating stem cells in nonhuman primates
Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
Alloantigen expression on non-hematopoietic cells reduces graft-versus-leukemia effects in mice
Neuropilin-1 promotes cirrhosis of the rodent and human liver by enhancing PDGF/TGF-β signaling in hepatic stellate cells
Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice
Hyperactivation of phosphatidylinositol-3 kinase promotes escape from hormone dependence in estrogen receptor–positive human breast cancer
Identification and validation of genes affecting aortic lesions in mice
CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow
NFAT/Fas signaling mediates the neuronal apoptosis and motor side effects of GSK-3 inhibition in a mouse model of lithium therapy
NMDA-induced neuronal survival is mediated through nuclear factor I-A in mice
The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice
E-selectin ligand–1 regulates growth plate homeostasis in mice by inhibiting the intracellular processing and secretion of mature TGF-β
Monocytic suppressive cells mediate cardiovascular transplantation tolerance in mice
Distinct roles for PTEN in prevention of T cell lymphoma and autoimmunity in mice
PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice
PINCH1 regulates Akt1 activation and enhances radioresistance by inhibiting PP1α
Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition
HIV-1 Rev–binding protein accelerates cellular uptake of iron to drive Notch-induced T cell leukemogenesis in mice
Elimination of C/EBPα through the ubiquitin-proteasome system promotes the development of liver cancer in mice
Conditional ablation of Ikkb inhibits melanoma tumor development in mice
An intracellular role for ABCG1-mediated cholesterol transport in the regulated secretory pathway of mouse pancreatic β cells
A molecular switch controls interspecies prion disease transmission in mice
Adrenal glucocorticoids have a key role in circadian resynchronization in a mouse model of jet lag
Murine induced pluripotent stem cells can be derived from and differentiate into natural killer T cells
Human keratinocytes are efficiently immortalized by a Rho kinase inhibitor
Myeloperoxidase-rich Ly-6C+ myeloid cells infiltrate allografts and contribute to an imaging signature of organ rejection in mice
Introduction of Stuart Kornfeld
Acceptance of the 2010 George M. Kober Medal
PET probes for distinct metabolic pathways have different cell specificities during immune responses in mice