In This Issue
What is the evidence for our standards of care?
Federal funding for stem cell research
The lady anatomist
The panic virus
Osteoimmunology at the nexus of arthritis, osteoporosis, cancer, and infection
Integrin α6β4 defines a novel lung epithelial progenitor cell
PON-dering differences in HDL function in coronary artery disease
Intestinal carcinogenesis
Absence of Stat1 in donor CD4+ T cells promotes the expansion of Tregs and reduces graft-versus-host disease in mice
Virus-induced tumor inflammation facilitates effective DC cancer immunotherapy in a Treg-dependent manner in mice
The LRF transcription factor regulates mature B cell development and the germinal center response in mice
The homeobox transcription factor VentX controls human macrophage terminal differentiation and proinflammatory activation
Attenuation of HIV-associated human B cell exhaustion by siRNA downregulation of inhibitory receptors
The VLDL receptor promotes lipotoxicity and increases mortality in mice following an acute myocardial infarction
Loss of H3K4 methylation destabilizes gene expression patterns and physiological functions in adult murine cardiomyocytes
Phosphodiesterase 4B in the cardiac L-type Ca2+ channel complex regulates Ca2+ current and protects against ventricular arrhythmias in mice
Mutations in KIF7 link Joubert syndrome with Sonic Hedgehog signaling and microtubule dynamics
FGF-dependent regulation of VEGF receptor 2 expression in mice
A ketogenic diet suppresses seizures in mice through adenosine A1 receptors
Ghrelin mediates stress-induced food-reward behavior in mice
Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease
Inhibition of PKCδ reduces cisplatin-induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer
The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors
Krüppel-like factor 4 regulates macrophage polarization
Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies
Multimodal silica nanoparticles are effective cancer-targeted probes in a model of human melanoma
Constitutive IKK2 activation in intestinal epithelial cells induces intestinal tumors in mice
Myeloid-derived suppressor cells are implicated in regulating permissiveness for tumor metastasis during mouse gestation
Engraftment of human nasal olfactory stem cells restores neuroplasticity in mice with hippocampal lesions
S6 kinase 1 is required for rapamycin-sensitive liver proliferation after mouse hepatectomy
Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts
Intrarenal dopamine deficiency leads to hypertension and decreased longevity in mice
Integrin α6β4 identifies an adult distal lung epithelial population with regenerative potential in mice
Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin αvβ8–mediated activation of TGF-β
Loss of Gata5 in mice leads to bicuspid aortic valve
Inhibition of MRP4 prevents and reverses pulmonary hypertension in mice
CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice
Absence of IFN-γ accelerates thrombus resolution through enhanced MMP-9 and VEGF expression in mice
Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis
P2X7 receptor signaling contributes to tissue factor–dependent thrombosis in mice
Sema3E–Plexin D1 signaling drives human cancer cell invasiveness and metastatic spreading in mice
The human visual cortex responds to gene therapy–mediated recovery of retinal function