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In This Issue
Politicizing NIH funding
For Huda Zoghbi, collaboration is the key to unlocking the secrets of neurobiology
Simpson
How cancer crossed the color line
Genetics of kidney failure and the evolving story of APOL1
Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling
Uroguanylin
Behind an enteric neuron there may lie a glial cell
Parkin reinvents itself to regulate fatty acid metabolism by tagging CD36
Peripheral glucose homeostasis
Finally! A human pancreatic β cell line
Enteric glia are multipotent in culture but primarily form glia in the adult rodent gut
Glial cells in the mouse enteric nervous system can undergo neurogenesis in response to injury
Renal collecting duct epithelial cells regulate inflammation in tubulointerstitial damage in mice
miR-107 promotes tumor progression by targeting the let-7 microRNA in mice and humans
Foxo1 is required in mouse spermatogonial stem cells for their maintenance and the initiation of spermatogenesis
Hedgehog/Notch-induced premature gliogenesis represents a new disease mechanism for Hirschsprung disease in mice and humans
Disruption of the histone acetyltransferase MYST4 leads to a Noonan syndrome–like phenotype and hyperactivated MAPK signaling in humans and mice
Gsα enhances commitment of mesenchymal progenitors to the osteoblast lineage but restrains osteoblast differentiation in mice
OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice
Plasma carboxypeptidase B downregulates inflammatory responses in autoimmune arthritis
Preclinical assessment of CNS drug action using eye movements in mice
Reduction of ER stress via a chemical chaperone prevents disease phenotypes in a mouse model of primary open angle glaucoma
Azithromycin blocks autophagy and may predispose cystic fibrosis patients to mycobacterial infection
IgE stimulates human and mouse arterial cell apoptosis and cytokine expression and promotes atherogenesis in Apoe–/– mice
A uroguanylin-GUCY2C endocrine axis regulates feeding in mice
A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion
Deficit of tRNALys modification by Cdkal1 causes the development of type 2 diabetes in mice
Human breast cancer cells enhance self tolerance by promoting evasion from NK cell antitumor immunity
Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulator
The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans
Regulatory B cells are identified by expression of TIM-1 and can be induced through TIM-1 ligation to promote tolerance in mice
Synergistic stimulation of type I interferons during influenza virus coinfection promotes Streptococcus pneumoniae colonization in mice
Nod2 sensing of lysozyme-digested peptidoglycan promotes macrophage recruitment and clearance of S. pneumoniae colonization in mice
Desmoglein 3–specific CD4+ T cells induce pemphigus vulgaris and interface dermatitis in mice
Enhancement of proteasomal function protects against cardiac proteinopathy and ischemia/reperfusion injury in mice
Parkin is a lipid-responsive regulator of fat uptake in mice and mutant human cells
Brain insulin action augments hepatic glycogen synthesis without suppressing glucose production or gluconeogenesis in dogs
Farnesoid X receptor represses hepatic human APOA gene expression
Disruption of PPARγ/β-catenin–mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival
A noninhibitory mutant of the caveolin-1 scaffolding domain enhances eNOS-derived NO synthesis and vasodilation in mice
Glycogen synthase kinase-3 is essential for β-arrestin-2 complex formation and lithium-sensitive behaviors in mice
Prolactin increases SMN expression and survival in a mouse model of severe spinal muscular atrophy via the STAT5 pathway