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A conversation with Rudolf Jaenisch
Advancing the mission
Medicine in 2055
Introduction of Francis S. Collins
All the Good People
A doctor’s dilemma
Cancer immunotherapy
From mice to humans
Immunity, inflammation, and cancer
Myeloid-derived suppressor cells in the tumor microenvironment
Tumor-induced myeloid deviation
Cytotoxic T lymphocyte antigen-4 and immune checkpoint blockade
Anti–PD-1/PD-L1 therapy of human cancer
CAR therapy
Therapeutic cancer vaccines
Tumor neoantigens
Hungry irony
It’s never too late to save a photoreceptor
A robust in vivo model for B cell precursor acute lymphoblastic leukemia
The tragic fate of group 3 innate lymphoid cells during HIV-1 infection
Alternatively spliced proline-rich cassettes link WNK1 to aldosterone action
Elevated copper impairs hepatic nuclear receptor function in Wilson’s disease
Kruppel-like factor 4 is critical for transcriptional control of cardiac mitochondrial homeostasis
Inflammatory IL-15 is required for optimal memory T cell responses
Rapamycin improves TIE2-mutated venous malformation in murine model and human subjects
Reversal of microRNA-150 silencing disadvantages crizotinib-resistant NPM-ALK(+) cell growth
Restoration of Na+/H+ exchanger NHE3-containing macrocomplexes ameliorates diabetes-associated fluid loss
Arginine methyltransferase PRMT5 is essential for sustaining normal adult hematopoiesis
A molecular trigger for intercontinental epidemics of group A Streptococcus
Analysis of conditional heterozygous STXBP1 mutations in human neurons
HDAC inhibitor–dependent transcriptome and memory reinstatement in cognitive decline models
RAP1-mediated MEK/ERK pathway defects in Kabuki syndrome
SLFN14 mutations underlie thrombocytopenia with excessive bleeding and platelet secretion defects
Mucosally transplanted mesenchymal stem cells stimulate intestinal healing by promoting angiogenesis
Sex ratio following preconception low-dose aspirin in women with prior pregnancy loss
Selective Treg reconstitution during lymphopenia normalizes DC costimulation and prevents graft-versus-host disease
Skin-derived neural precursors competitively generate functional myelin in adult demyelinated mice
DNA replication stress underlies renal phenotypes in CEP290-associated Joubert syndrome
Comparative genomics reveals multistep pathogenesis of E2A-PBX1 acute lymphoblastic leukemia
Adipocyte iron regulates leptin and food intake
Plasmacytoid dendritic cells promote HIV-1–induced group 3 innate lymphoid cell depletion
Halting progressive neurodegeneration in advanced retinitis pigmentosa
The cortical thickness phenotype of individuals with DISC1 translocation resembles schizophrenia
Biomarkers on patient T cells diagnose active tuberculosis and monitor treatment response
Fibrinolysis is essential for fracture repair and prevention of heterotopic ossification