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Promoting a culture of safety involves a philosophical shift from error measurement to proactive assessment of potential harm. Failure Mode and Effect AnalysisTM (FMEA) is a prospective risk analysis technique that can be used to examine the chemotherapy administration process. FMEA is a systematic, multidisciplinary team-based approach to error prevention. This article reviews the process of conducting FMEA and provides suggestions on how FMEA can be applied to the chemotherapy administration process. Nurses who are knowledgeable about risk analysis techniques and the process for applying them in clinical practice have the potential to promote a culture of safety for patients receiving chemotherapy.