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Cervical cytology in the form of a Papanicolaou test has been an invaluable tool in reducing the worldwide incidence of invasive cervical cancer. Human papilloma virus (HPV) 16 is the most common genotype detected in both cervical intraepithelial neoplasia 3/carcinoma in-situ and invasive cancer. This is a case of a 50-year-old nulligravid woman who developed HPV 16-positive squamous cell carcinoma of the left fallopian tube and ovary 15 years after undergoing a vaginal hysterectomy for recurrent high-grade dysplasia. A review of the literature demonstrated that the case most likely represents delayed metastatic spread rather than a primary HPV 16-associated lesion of the adnexa.