IN THIS ISSUE
Pharmaceutical Relevance of Drug Transporter Malfunctions
HIGHLIGHTS
ASCPT NEWS
Transporter-Mediated Drug- Drug Interactions
The Placebo response is Part of Good Medicine
Clinical Trials of Antidepressants: “Enrichment Strategies”
Response to “Clinical Trials of Antidepressants: ‘Enrichment Strategies’” and “The Placebo Response Is Part of Good Medicine”
Validation and Predictive Performance Assessment of Clinical Trial Simulation Models
Response to “Validation and Assessment of Predictive Performance in Simulation Models of Clinical Trials”
Prevalence and Clinical Utility
Response to “Prevalence and Clinical Utility”
Multidrug Efflux Pumps and Cancer Stem Cells: Insights Into Multidrug Resistance and Therapeutic Development
The Value and Benefits of the international Conference on Harmonisation to Drug Regulatory authorities: advancing Harmonization for Better public Health
Immunoconjugates Against Solid Tumors: Mind the Gap
Drug Interactions Between the Immunosuppressant Tacrolimus and the Cholesterol Absorption Inhibitor Ezetimibe in Healthy Volunteers
Challenges in Obtaining Adequate Genetic Sample Sets in Clinical Trials: The Perspective of the Industry Pharmacogenomics Working Group
Coding of DNA Samples and Data in the Pharmaceutical Industry: Current Practices and Future Directions—Perspective of the I-PWG
Current practices for DNa Sample Collection and Storage in the pharmaceutical industry, and potential areas for Harmonization: perspective of the I-PWG
Global Requirements for DNA Sample Collections: Results of a Survey of 204 Ethics Committees in 40 Countries
Concurrent Assessment of Hepatic and Intestinal Cytochrome P450 3A Activities Using Deuterated Alfentanil
Functional Characterization of Liver Enhancers That Regulate Drug-Associated Transporters
Mechanism-Based Inactivation of CYP2C8 by Gemfibrozil Occurs Rapidly in Humans
Preserved Response to Diuretics in Rosiglitazone-Treated Subjects With Insulin Resistance: A Randomized Double-Blind Placebo-Controlled Crossover Study
Benzodiazepine-Like Hypnotics and the Associated Risk of Road Traffic Accidents
From Trial and Error to Trial Simulation III: A Framework for Interim Analysis in Efficacy Trials With Antidepressant Drugs
OCT-1 as a Determinant of Response to Antileukemic Treatment
Use of Transgenic and Knockout Mouse Models to assess Solute Carrier Transporter Function
A New Trend in Personalized Medicine: Rapid Detection of SNPs in Drug Transporter Genes by the SmartAmp Method
Inhibition of SGLT2: A Novel Strategy for Treatment of Type 2 Diabetes Mellitus