Reevaluation of Some Double-Blind, Randomized Studies of Dexibuprofen (Seractil): A State-of-the-Art Overview Studies in Patients with Lumbar Vertebral Column Syndrome, Rheumatoid Arthritis, Distortion of the Ankle Joint, Gonarthrosis, Ankylosing Spondylitis, and Activated Coxarthrosis


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Abstract

This article presents a reevaluation of studies previously performed regarding the efficacy and safety of dexibuprofen (Seractil; S(+)-ibuprofen) for use in patients with inflammatory or degenerative diseases. Using appropriate standardized measures (univariate and multivariate analysis with the Mann-Whitney statistic with confidence intervals), the authors were able to compare the effects of treatment in different diseases. For the primary criterion and for the combined analysis of all efficacy criteria, one-sided equivalence was proved in all six studies reviewed.

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