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Standards for Research (StaR) in Child Health was founded in 2009 to address the paucity and limitations of pediatric clinical trials. This initiative brings together international experts who are committed to developing practical, evidence-based standards to enhance the quality, ethics and relevance of clinical research in child health. By employing a systematic ‘knowledge to action’ plan, StaR Child Health creates opportunities to develop the evidence base for treatment of children around the world. To date, six StaR standards have been published with additional tools and standards are currently under development. Broad acceptance of research quality standards in child health can ultimately advance healthcare provided to children across the globe and enhance health outcomes.