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Feldner, Zvolensky, and Schmidt (this issue) summarize the main findings from studies on universal, selected, and indicated prevention programs as they relate to anxiety psychopathology. Based on their review, Feldner et al. outline a number of conclusions about the status of the empirical literature on the prevention of anxiety and discussed several directions for future research. In this commentary, I focus on some key issues related to prevention research and practice: (a) the definition of prevention; (b) the need for increased emphasis on causal mechanisms; (c) the importance of broad-based assessment; and (d) issues related to cost effectiveness, readiness for change, and dose-response relationships.