Suicide Associated with Akathisia and Depot Fluphenazine Treatment

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AKATHISIA is a common and distressing side effect of neuroleptic medication that can he difficult to recognize and treat,1 Several previous reports mention maladaptive behavioral consequences, such as poor compliance with prescribed medication2 and aggressive or self-destructive outbursts2–3 We are reporting suicides in two young Hispanic men who had developed severe akathisia after treatment with depot fluphenazine. Depression with suicidal behavior has been observed following fluphenazine injection,4 but suicide associated with akathisia has not been previously noted.

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