Treating Human Immunodeficiency Virus–Associated Pulmonary Arterial Hypertension: Is Endothelin 1 a Target?

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Synopsis:In 16 prospectively treated patients with human immunodeficiency virus–associated pulmonary hypertension, use of bosentan improved 6-minute walk distances, cardiopulmonary hemodynamics, New York Heart Association functional class, and quality-of-life measures. In addition, there appeared to be no untoward side effects or drug interactions.Source:Sitbon O et al. Bosentan for the treatment of human immunodeficiency virus-associated pulmonary arterial hypertension. Am J Respir Crit Care Med. 2004;170:1212–1217.

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