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The addition of inhaled iloprost in patients with pulmonary arterial hypertension with reduced exercise capacity already on bosentan monotherapy is safe and efficacious.McLaughlin VV, Oudiz RJ, Frost A, et al. Randomized study of adding inhaled iloprost to existing bosentan in pulmonary arterial hypertension. (STEP study: Safety and pilot efficacy Trial in combination with bosentan for Evaluation in Pulmonary arterial hypertension). Am J Respir Crit Care Med. 2006;174:1257–1263.