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Low-dose hydrocortisone therapy does not decrease mortality in patients who did or did not have a response to corticotropin, which is a reversal of previous study outcomes. Hydrocortisone does reverse shock faster but there may be an associated increase in secondary infections.Sprung CL, Annane D, Keh D, et al. Hydrocortisone therapy for patients with septic shock. N Engl J Med. 2008;358:111–124.