Does Cardiac Morphology Predict Plasma Brain Natriuretic Peptide Levels in Adolescent Athletes?

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Objective:The purpose of this study was to establish the relationship of plasma levels of brain natriuretic peptide (BNP) to physiologic parameters and cardiac morphologic characteristics in a population of young athletes. Our hypothesis is that physiologic and cardiac morphologic characteristics do not predict BNP levels in adolescent athletes.Design:Observational study.Setting:Outpatient hospital.Participants:Thirty healthy male adolescent high school football players (16.0 ± 1.1 years).Interventions:Physical exam, electrocardiography, plasma BNP measurement by rapid fluorescent immunoassay, and limited echocardiography.Main Outcome Measures:Null hypothesis-physiologic parameters and cardiac morphology do not predict plasma BNP levels in healthy adolescent football players. Significance level set at P < 0.05.Results:Plasma BNP for this population was 11.9 ± 10.2 pg/mL. There was no correlation between BNP and mean arterial pressure (r = −0.09, P = 0.64), body mass index (r = 0.11, P = 0.57), interventricular septal thickness (r = −0.15, P = 0.44), left ventricular (LV) wall thickness (r = 0.00, P = 0.99), relative wall thickness (r = −0.04, P = 0.84), LV mass (r = 0.05, P = 0.79), or LV mass index (r = 0.11, P = 0.55).Conclusions:Plasma BNP levels in healthy adolescent athletes have no correlation to body mass index or LV mass, even when corrected for body surface area.

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