The association between statins and telomere shortening

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Abstract

Statins are well-established drugs for primary and secondary prevention of cardiovascular diseases. Many statin cholesterol-lowering independent actions, known as ‘pleiotropic effects’, have been identified in different cell types, including modulation of inflammation, oxidative stress, apoptosis, cell proliferation, immune response and platelet aggregation. Recent evidence suggested an additional pleiotropic effect of statins on cellular senescence mediated by their interaction with telomere maintenance system. In this special report, we will present the most important findings regarding the association between statins therapy and telomere dynamic.

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