The sleep profiles of healthy adult volunteers (group 1) were compared with the sleep profiles of depressive patients (group 2), using the method suggested by Görtelmeyer. This method uses a questionnaire to evaluate the various aspects of sleep profiles that may be different in depressive patients compared with healthy subjects. Thirty patients in group 2 were tested before and during exposure to moclobemide (450 mg/day) for 8 weeks. The group of healthy adults did not receive moclobemide and showed stable sleep profiles throughout the study period. After approximately 2 weeks of administration of moclobemide, the sleep profiles of depressive patients that had been aberrant at baseline became more normal. Around this same time, the antidepressant effects of moclobemide became apparent. The sleep questionnaire used in this study appears to be a valuable and practical method for evaluating sleep architecture.