Reversible Tremor, Myoclonus, and Fasciculations Associated with Topiramate Use for Migraine

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To report a patient with tremor, multifocal myoclonus, and fasciculations, possibly induced by the antiepileptic drug topiramate.

Case Report:

A 46-year-old woman with frequent episodes of migraine without aura that were not controlled with other prophylactic drug, developed a reversible clinical picture of postural tremor, multifocal myoclonus, weight loss, amyotrophia, and fasciculations after exposure to topiramate. These symptoms disappeared after topiramate withdrawal.


Tremor, myoclonus, and fasciculations should be considered as a possible adverse effect of topiramate.

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