Lamotrigine Serum Concentrations Throughout the Menstrual Cycle-A Study of 2 Cases

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Abstract

Objectives:

To measure the serum concentrations of lamotrigine throughout a complete menstrual cycle.

Methods:

Serum concentrations of lamotrigine, estradiol, and progestogen throughout a menstrual cycle were measured in 2 young women not using hormonal contraception.

Results and Conclusions:

The physiological hormonal fluctuations during an ovulatory cycle were not associated with clinically relevant changes in lamotrigine serum concentrations.

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