In a prospective analysis, healthy women known to be carriers of BRCA1 or BRCA2 mutations chose either bilateral mastectomy or active surveillance. Ascribing to careful methodological detail, the investigators found that those who chose surgery had lower risk for breast cancer occurrence and better survival. nonetheless, the authors note that longer follow-up and a larger sample size are needed to confirm statistical significance of their observations.SOURCE:
Heemskerk-Gerritsen BA, et al. Substantial breast cancer risk reduction and potential survival benefit after bilateral mastectomy when compared with surveillance in healthy BRCA1 and BRCA2 mutation carriers: A prospective analysis. Ann Oncol 2013;24:2029-2035.