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Tc-99m DTPA renal imaging has been routinely used in postrenal transplant evaluation. A patient's Tc-99m DTPA studies after transplantation are presented, showing a large photon-deficient area in the region of the allograft on the third postoperative day. The photondeficient area is two to three times larger than that seen in the original, functioning allograft on the first postoperative day. Enlarged to a weight of 530 g, the allograft on gross and microscopic examination confirmed renal vein thrombosis. Enlargement of the photon-deficient area at the anatomic site of the allograft indicates a scintigraphic pattern of renal vein occlusion incompatible with a viable allograft.