We report a case of carotid chemodectoma diagnosed by 111In pentetreotide SPECT/CT. A 72-year-old woman with an ileocecal neuroendocrine tumor underwent whole-body 111In pentetreotide scintigraphy for exclusion of distant metastases. Planar scintigraphy demonstrated marked tracer uptake in the ileocecal region and intense focal tracer accumulation within the neck. SPECT/CT demonstrated a space-occupying lesion at the carotid bifurcation. Histopathological evaluation revealed carotid chemodectoma. SPECT/CT is a valuable tool for the evaluation and precise anatomical localization of tracer uptake. In addition, other benign or malignant pathologies accumulating 111In pentetreotide may mimic neuroendocrine tumor metastases and should be considered particularly in unusual localizations.