A 59-year-old transexual (male to female) patient presented with a squamous cell carcinoma of the larynx. She underwent an 18F-FDG PET/CT for initial staging. The examination showed high 18F-FDG uptake of the primary lesion and a homolateral lymphadenopathy. Incidental heterogeneous uptake of round hyperdense lesions in the gluteal muscles and subcutaneous fat was visualized. The medical history revealed secondly that the patient had had free liquid silicone injections 30 years before the examination. Although the injection of free silicone is not practised since the 1980s, this incidental finding should prompt to check the patient’s medical history over several decades.