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68Ga-labeled prostate-specific membrane antigen (PSMA) is a potential tool in the imaging of recurrent prostate cancer. 68Ga-PSMA imaging is also useful for radiotherapy planning and in targeted therapy with 177Lu-PSMA. A few case reports regarding the use of 68Ga-PSMA in nonprostate cancer malignancies are also reported. We describe the use of 68Ga-PSMA imaging before 153Sm-EDTMP bone pain palliation therapy in a 58-year-old hormone refractory prostate cancer patient with extensive bone metastases.