18F-FDG PET/CT Evaluation of Ceritinib Therapy in Metastatic ALK-Positive Non–small Cell Lung Cancer

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Anaplastic lymphoma kinase (ALK)–positive non–small cell lung cancers (NSCLC) account for 3% to 7% of all NSCLC and require a standard treatment by crizotinib. However, crizotinib resistance is frequent within the first 12 months of treatment. Ceritinib is a novel tyrosine kinase inhibitor of ALK recently introduced in France for metastatic or locally advanced crizotinib-resistant ALK NSCLC. We report the first use of ceritinib in our institution with a spectacular tumoral response after only 3 months of treatment. This case demonstrates the major role of 18F-FDG PET/CT for monitoring the effectiveness of this new treatment.

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