18F-NaF and 18F-FDG PET/CT in Gorham-Stout Disease

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Gorham-Stout disease (GSD) is an extremely rare skeletal disorder of unknown etiology characterized by benign proliferation of vascular or lymphatic channels, leading to progressive bone resorption. We report on a patient diagnosed with GSD affecting the right scapula and the right ribs, who underwent PET/CT scans using 18F-FDG and 18F-NaF. The remnant upper portion of the affected scapula did not show 18F-FDG uptake but demonstrated markedly increased 18F-NaF activity. Furthermore, intense 18F-NaF activity was seen on the right posterior ribs, which were actively being resorbed, suggesting the potential application of 18F-NaF-PET/CT imaging in GSD diagnosis and follow-up.

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