Fibrous Dysplasia Mimicking Malignancy on 68Ga-DOTATATE PET/CT

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Abstract

Fibrous dysplasia of the bone is a developmental benign skeletal disorder characterized by replacement of normal bone and normal bone marrow with abnormal fibro-osseous tissue. We report on a case of a biopsy-proven fibrous dysplasia lesion in the left temporal bone, with intensely increased activity (SUVmax, 56.7) on 68Ga-DOTATATE PET/CT. The presented data indicate cell surface overexpression of somatostatin receptors by fibrous dysplastic cells and highlight the need of cautious management of 68Ga-DOTATATE–avid bone lesions, which could mimic malignancy especially in patients with history of neuroendocrine tumors.

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