Avascular Necrosis of the Hips With Increased Activity on 68Ga-DOTATATE PET/CT

    loading  Checking for direct PDF access through Ovid

Abstract

Prolonged exposure to cortisol is one of the major causes of avascular bone necrosis (AVN). We report on a case of a woman with Cushing syndrome attributed to ectopic adrenocorticotropic hormone–secreting tumor who was evaluated with whole-body PET/CT study using 68Ga-DOTATATE. The scan showed increased activity by both femoral heads, corresponding to the margins of bilateral AVN seen on MRI. The presented data suggests AVN-induced reactive inflammatory alterations adjacent to the necrotic segment of the bone, which can be effectively targeted using radiolabeled somatostatin (SST) analogs.

Related Topics

    loading  Loading Related Articles