Prostate-Specific Membrane Antigen PET/CT: Uptake in Lymph Nodes With Active Sarcoidosis

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We describe 2 cases of 68Ga-PSMA PET/CT in prostate cancer patients. Both cases demonstrated symmetrical bilateral involvement of mediastinal and hilar lymph nodes besides findings in relation with prostatic disease. In both cases, endobronchial ultrasound-guided biopsy showed that the involvement of the thoracic lymph nodes was caused by nonnecrotic granulomas compatible with sarcoidosis. The cases demonstrated that increased 68Ga-PSMA uptake can be seen in lymph nodes with active sarcoidosis, with images mimicking those well known from 18FDG PET/CT. Because of these findings, granulomatous disease has to be included in the differential diagnostic evaluation of patients with 68Ga-PSMA–positive lymph nodes.

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