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A 76-year-old man underwent 18F-FDG PET/CT to complete staging and characterize a suspicious lung mass. Images showed intense uptake in the lung lesion and faint uptake in correspondence of a gastric mass, which was subsequently biopsied revealing a gastrointestinal stromal tumor. A 18F-FAZA PET/CT was also performed because of patient’s enrollment in a prospective clinical trial (trial registration no. EudraCT 2011-002647-98), showing heterogeneous uptake of 18F-FAZA in the pulmonary lesion and faint uptake in correspondence of the gastrointestinal stromal tumor.