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We present the findings on 18F-FDG PET/CT in a 50-year-old man known to self-administer intramuscular injections with site enhancement oil in the upper extremities. PET images show diffuse pathological high FDG uptake in soft tissue of the upper arms and in scanned portions of the forearms. On the CT images, the muscles in the upper arm are swollen with a moth-eaten appearance and surrounding edema. Interspersed in the muscle tissue are several “cystic” lesions interpreted as oil deposits termed oleomas.