68Ga-PSMA PET/MR–Positive, Histopathology-Proven Prostate Cancer in a Patient With Negative Multiparametric Prostate MRI

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Abstract

Multiparametric MRI incorporating T2-weighted, diffusion-weighted, and dynamic contrast material–enhanced sequences is currently used for detection and localization of clinically important prostate cancer (PCa). The 68Ga-labeled PET tracer targeting the prostate-specific membrane antigen (PSMA, 68Ga-PSMA-11) is a promising diagnostic approach for staging and restating PCa. Recent studies suggest that 68Ga-PSMA could also be used for primary PCa detection and localization. We report a case of a 68Ga-PSMA PET/MR-positive lesion of the peripheral zone in a 73-year-old man with a negative preceding multiparametric MRI. Radical prostatectomy and subsequent histopathologic examination confirmed a Gleason 4 + 4 PCa.

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