This article gives a brief pathobiologic explanation of the etiology of hemorrhage in the adult leukemic patient. Evaluation of the platelet count, altered clotting mechanism and the ramifications of major hemorrhage are addressed. Included also are aspects of platelet transfusions, specifically their indication for use, prophylaxis, and complications. This discussion precedes the nursing protocol so that some understanding of the hemorrhagic phenomenon in leukemics can be facilitated. The protocol itself and some brief introductory information are outlined so that the protocol can be inserted into the patient's chart for reference in meeting nursing care objectives for this classification of patients.