The establishment of a nurse-run Chemotherapy Clinic in a Veterans Administration Medical Center is described. The reason for its founding, why a nurse was chosen and her qualifications, and the lines of responsibility within the hospital are outlined. The physical layout, day-to-day operation of the Clinic, and initial problems encountered are explained. The scope of practice of the nurse practitioner and the legal aspects of this new expanded role in the oncological setting are addressed. The author shares a view of her evolving philosophic stance for her practice, and its potential value in determining the thrust of cancer nursing in the future.