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Chemotherapy-induced nausea and vomiting (CINV) affects cancer patients’ quality of life, despite the provision of antiemetic medication.The aim of this study is to assess the clinical effectiveness of the hologram bracelet in the management of CINV among adult patients with cancer.An experimental, double-blinded design spanning 3 courses of chemotherapy was used; 175 oncology patients were randomly assigned to 3 groups: placebo (n = 53), control (n = 54), and intervention (hologram bracelet) (n = 68). Daily diaries were used to detect the severity and the frequency of CINV and to detect the frequency of using antiemetic medications. The Functioning Living Index–Emesis was used to examine the impact of CINV on the activities of daily living.Significant CINV differences existed between groups. The mean total Functioning Living Index–Emesis score was significantly lower in the intervention group for total vomiting and total nausea.Hologram bracelet use among patients with cancer had a positive effect on CINV. The level of CINV decreased and activity of daily living scores increased. However, effects varied among the types of CINV.Further study is recommended to explore the benefits of the bracelet.