Calcium metabolism in the normal and diseased heart

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The complexity of excitation-contraction coupling is emphasized by theoretical studies which suggest the requirement for microdomains of Ca2+ Within the cytoplasm of the cardiac myocyte. Our understanding of the various changes in Ca2+ metabolism during development and disease, as well as the critical role of Ca2+ regulation by Na-Ca exchange and intracellular Na+ concentration, is becoming more clearly defined, providing possibilities for intervention.

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