Nitric oxide and anesthetics

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There is a growing understanding of the significant and varied roles that endogenous nitric oxide (NO) plays in the control of the circulation in both normal and diseased states. Recent reports indicate that anesthetics interfere with the production of NO in the endothelium; thay may also affect its dilating actions within vascular smooth muscle. Several studies suggest that halogenated anesthetics may attenuate NO-dependent vascular relaxation by competing with NO for its binding site on the iron of the heme-containing enzyme, guanylyl cyclase.

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