High-density lipoprotein metabolism and progression of atherosclerosis: new insights from the HDL Atherosclerosis Treatment Study

    loading  Checking for direct PDF access through Ovid

Abstract

Purpose of review

The purpose of this review is to summarize the current understanding of the potentially antiatherogenic properties of high-density lipoprotein related to its different components.

Recent findings

Recent findings on the role of the different high-density lipoprotein subspecies in reverse cholesterol transport, inflammation, endothelial dysfunction, and low-density lipoprotein oxidation are covered. Special emphasis is put on the heterogeneity of high-density lipoprotein and functional changes related to specific high-density lipoprotein particles with the potential therapeutic alterations of high-density lipoprotein metabolism.

Summary

The diverse action of high-density lipoprotein observed could be explained by the heterogeneity of high-density lipoprotein particles with completely different composition and properties. The modification of specific high-density lipoprotein subpopulations to reach the maximum atheroprotective effects under various pathologic conditions bears great potential in lipid research.

Related Topics

    loading  Loading Related Articles