The metabolic effects of enterally administered ribonucleic acids

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Roles for dietary sources of preformed purines and pyrimidines such as RNA in various systems have been demonstrated in recent years. These include maintenance of a competent immune system, gut development, hepatic function and many others, with a central theme of rapidly dividing cells requiring these compounds for optimal function. These compounds were previously thought to be non-essential but are now considered to be conditionally required when various stresses, including rapid growth and infection, are present. A number of recent studies are summarized that cover a variety of areas and are consistent with critical roles for dietary sources of nucleotides for many cellular functions.

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