HIV infection and endocrine disease

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The endocrine system recently has become appreciated as a potential target site for HIV infection. Abnormal endocrine gland function can occur as a result of direct HIV Infection, secondary infectious or malignant processes, or as a complication of therapies for AIDS. In this context, the adrenals are most important because unrecognized adrenal insufficiency in AIDS inevitably will lead to rapid demise of the patient. Fortunately, frank adrenal insufficiency is most uncommon. Also. uncommon are clinical manifestations of other endocrine organ dysfunction, but the thyroid gland, pancreas, and gonads are all potential targets. Electrolyte abnormalities and disordered energy metabolism are additional potential complications of HIV infection

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