Accelerating access and scale-up of optimized ART in low-income and middle-income countries: a call for a coordinated end-to-end approach

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Purpose of review

To discuss how aligning the collective power of scientists, regulators, drug companies, donors, implementers and advocates to achieve a single goal – accelerating access to simpler, safer, more robust and more affordable HIV treatment – can rapidly advance antiretroviral optimization efforts and enable scale-up.

Recent findings

Harmonization of traditionally sequential processes can address the delays commonly experienced in introducing new products to low-income and middle-income countries, by facilitating an ‘end-to-end’ approach that mitigates risk and encourages early planning for all aspects of product introduction.


Planning with the ‘end-in-mind’ can facilitate healthy markets, benefit the application of new technologies, and accelerate the development of improved products in parallel (versus traditionally sequential efforts).

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