Therapy of HIV-1 infection

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Many new agents are currently being evaluated in clinical trials to determine their efficacy in treating patients infected with HIV-1. Nucleoside analogs which inhibit HIV reverse-transcriptase continue to be the mainstay of therapy. Recent observations, published during this review period, questioned the most appropriate time to initiate antiretroviral therapy and have forced the re-examination of previous recommendations. This review will address the recent and significant findings for monotherapy, combination therapy and immunotherapy for HIV-1 infection and discuss the trend towards a more individualized therapeutic approach in managing patients infected with HIV-1.

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