Alzheimer's disease and related dementias

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Abstract

New studies have implicated both the amyloid-precursor gene on chromosome 21 and the apolipoprotein-E (APOE) gene on chromosome 19 in the etiology of subtypes of Alzheimer's disease (AD). Clinical trials have demonstrated that tacrine, a cholinesterase inhibitor, has real, but limited use as a treatment for AD. Genetic testing of individuals at risk for Huntington's disease (HD) is posing new challenges for therapy and genetic counseling.

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