Mood and anxiety disorders are the most prevalent psychiatric conditions in organ transplantation.Risk factors for these disorders in transplant populations include psychiatric history and gender, and may also include social supports and coping style. There is consistent evidence that mental health outcomes, both diagnosable disorder and psychiatric symptom levels, improve from pretransplant to post-transplant. However, follow-up periods have generally been brief. There is little evidence as to whether psychiatric morbidity rates and risk factors change in the extended years post-transplant. Curr Opin Psychiatry 11:621-626.