Parathyroid hormone (1-34) compensates the negative effect of smoking around implants

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This study aimed to investigate the effect of Recombinant Human Parathyroid Hormone (PTH 1-34) on attenuating the influence of cigarette smoke on bone around titanium implants.

Material and methods

Forty-eight female Wistar rats were used. At the begging of the study, 15 animals were randomly assigned to Group 1 (control) and received subcutaneous injections of saline solution, three-times/week, after implant placement. The other animals received intermittent cigarette smoke inhalation (CSI), 60 days prior and 60 days after implant placement (Al2O3-blasted titanium implants – 4.0 × 2.2 mm). After surgery, these animals were randomly assigned to: Group 2 – subcutaneous injections of saline solution, three-times/week (n = 16) and Group 3 – intermittent doses of PTH (1-34) (40 μg/Kg), three-times/week (n = 17). Animals were sacrificed 60 days after surgery, and degree of bone-to-implant contact (BIC), bone area (BA) within the limits of the threads and proportion of mineralized tissue (PMT) adjacent to the implants (500 μm wide zone) were separately obtained in cortical and cancellous bone.


Data analysis confirmed that CSI negatively affects bone around implants, as observed for BIC in cortical zone (Cohen's d (d) = −1.26) and for PMT in both zones (d = −6.09 and d = −4.46 for cortical and cancellous zones, respectively). In addition, in the presence of CSI, PTH (1-34) promoted the highest BIC in both regions and BA and PMT in cancellous bone (P < 0.05). The histometric parameter that was not influenced by both PTH and CSI (1-34) was BA in cortical bone (P > 0.05).


In the presence of cigarette smoke, a factor related to poor bone healing and low bone density, PTH (1-34) increased bone volume around implants.

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