Bone neo-formation and mineral degradation of 4Bone.® Part II: histological and histomorphometric analysis in critical size defects in rabbits

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To carry out the histological and histomorphometric plus radiological analysis of biphasic ceramic.

Materials and method:

In this study, porous HA/βTCP (4Bone®) ceramic material was tested for the bone repairing capacity and osteoinductive potential in a New Zealand rabbit model. The ratio of the ceramic′s components HA/βTCP was 60/40 (in wt%).


The 4Bone® showed significantly more bone formation in the pores and in the periphery of the graft than the control group. Histomorphometric analysis revealed that the ceramic material (66.43% ± 0.29) produced higher values of bone-to-implant contact (BIC) percentages (higher quality, closer contact); moreover, defect closure was significative higher in relation with control group (64.15% ± 3.52).


4Bone® is a biocompatible, partially resorbable and osteoconductive grafting material. Biphasic graft material of HA/βTCP with a porosity of 95% without loading favors new bone formation.

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