Antiphospholipid antibodies and cardiovascular disease

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It is exactly 10 years since we described the features of the anticardiolipin syndrome — arterial and venous thrombosis, strokes, migraine, livedoreticularis, recurrent abortion and occasional thrombocytopenia. Other features of what is now widely known as the antiphospholipid syndrome are labile hypertension, chorea, amaurosis fugax, epilepsy, heart valve disorders, chronic (venous) leg ulcers and myelitis. At present both the pathogenesis and the optimal management of the syndrome are uncertain.

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